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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically focused on practical aspects of the research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and lessen the chance of bias, 프라그마틱 정품 확인법 슬롯 무료체험 (https://kingslists.com/story19447992/where-is-Pragmatic-casino-be-one-year-from-now) is also necessary. Too much heterogeneity, however, can cause problems with the trial design.

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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be a great way to identify the causal relationship between an intervention and its results. However, they should not be used to substitute for the use of explanation trials.

The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial, including the recruitment process, the design and implementation of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.